What is MDS – Myelodysplastic syndrome?

What is MDS – Myelodysplastic syndrome?

MDS - Myelodysplastic syndrome is a hematopoietic stem cell disorder that affects the bone marrow. A spectrum of risk, from low to very high, is measured by IPSS - R scores. US prevalence estimate is 59,000; 18,000 have higher risk MDS. Treatment options limited to hypomethylating agents (HMAs) Vidaza (Celgene); Dacogen (Eisai/J&J). Both approved a decade ago. No second - line treatment approved.

What is a monoclonal antibody?

A monoclonal antibody or mAb is an antibody produced in the laboratory from a single ancestral plasma cell

What Is Non-Hodgkin Lymphoma?

Non-Hodgkin lymphoma (also known as non-Hodgkin’s lymphoma or NHL) is a cancer of the lymphocytes, a type of white blood cells and an important part of the immune system.

What is INI1 and SMARCA4?

INI1 and SMARCA4 are subunits of SWI/SNF, a chromatin modifying protein complex, which opposes the activity of PRC2, the complex within which EZH2 resides.