What is Intent-to-treat population or ITT?

What is Intent-to-treat population or ITT?

Intent-to treat population is the total number of patients randomized at the beginning of a trial. Now, in an actual trial, a number of patients may drop out or otherwise fail to complete the trial. If these drop outs are taken into account during the trial analysis, results may be skewed. As an example, let’s consider a trial of two weight loss drugs, one more effective than the other. Now, during the trial, patients in the more effective drug arm may find themselves losing weight quickly, and decide to drop out because they have already achieved weight loss. What remains in this arm are those that did not lose enough weight.

In the other arm with the less effective drug, the opposite happens. Many people don’t have any weight loss at all, and these drop out. A few have just a little weight loss, and continue to remain in hopes of seeing better results. So, in effect, what remains are people who have seen some effect. In the other arm, we will recall, patients that remained were those that saw little effect.

Now, if we do not consider the drop outs, and only analyze the existing population, it may look like the less effective drug is more effective!

That is why, nowadays, all clinical trials use the ITT population; that is, everyone that came in for the trial, irrespective of those that dropped out for whatever reasons. The ITT gives a more randomized analysis.

What is a monoclonal antibody?

A monoclonal antibody or mAb is an antibody produced in the laboratory from a single ancestral plasma cell

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Non-Hodgkin lymphoma (also known as non-Hodgkin’s lymphoma or NHL) is a cancer of the lymphocytes, a type of white blood cells and an important part of the immune system.

What is INI1 and SMARCA4?

INI1 and SMARCA4 are subunits of SWI/SNF, a chromatin modifying protein complex, which opposes the activity of PRC2, the complex within which EZH2 resides.