What is a Hypomethylating agent or HMA?

What is a Hypomethylating agent or HMA?

Hypomethylating agent - or HMA, are hypomethylating or demethylating agents. DNA methylation is an epigenetic process that adds a methyl group to the DNA strand and can lead to inappropriate silencing of, for example, tumor suppression genes, leading to tumor growth. Demethylation agents like the approved drugs azacitidine and decitabine remove this methyl group in some populations and are thought to have an effect in controlling tumor growth in certain cancers like Myelodysplastic syndrome.

What is a monoclonal antibody?

A monoclonal antibody or mAb is an antibody produced in the laboratory from a single ancestral plasma cell

What Is Non-Hodgkin Lymphoma?

Non-Hodgkin lymphoma (also known as non-Hodgkin’s lymphoma or NHL) is a cancer of the lymphocytes, a type of white blood cells and an important part of the immune system.

What is INI1 and SMARCA4?

INI1 and SMARCA4 are subunits of SWI/SNF, a chromatin modifying protein complex, which opposes the activity of PRC2, the complex within which EZH2 resides.