What is a monoclonal antibody?

What is a monoclonal antibody?

A monoclonal antibody or mAb is an antibody produced in the laboratory from a single ancestral plasma cell, a type of white blood cell, a part of the immune system, that secrets large quantities of natural antibodies. An mAb can be used to augment the immune system's cancer fighting ability. An antibody binds to an antigen, and antigens are found in larger numbers on the surface of cancer cells. Thus, monoclonal antibodies offer targeted cancer therapy.

Monoclonal antibodies are more difficult to produce than small molecule drugs, and especially fully humanized monoclonal antibodies. Therefore, they are usually more expensive. However, generics of biologic drugs like mAbs are also difficult to produce, so mAbs have that advantage.

Some of the most well known drugs are monoclonal antibodies. MAbs are used to flag cancer cells, deliver cytotoxic agents targeting cancer cells, inhibit angiogenesis or blood vessels necessary for tumor survival, inhibiting immune system inhibitors triggered by cancer cells, or as diagnostic tools.Rituxan, Humira, Avastin and Herceptin are well known monoclonal antibody drugs.

What is a monoclonal antibody?

A monoclonal antibody or mAb is an antibody produced in the laboratory from a single ancestral plasma cell

What Is Non-Hodgkin Lymphoma?

Non-Hodgkin lymphoma (also known as non-Hodgkin’s lymphoma or NHL) is a cancer of the lymphocytes, a type of white blood cells and an important part of the immune system.

What is INI1 and SMARCA4?

INI1 and SMARCA4 are subunits of SWI/SNF, a chromatin modifying protein complex, which opposes the activity of PRC2, the complex within which EZH2 resides.