What Is Non-Hodgkin Lymphoma?

What Is Non-Hodgkin Lymphoma?

Non-Hodgkin lymphoma (also known as non-Hodgkin’s lymphoma or NHL) is a cancer of the lymphocytes, a type of white blood cells and an important part of the immune system. Of these, B Cell lymphoma is more common in the USA than T Cell lymphoma.

Indolent lymphomas like follicular lymphomas grow slowly, while aggressive ones, like diffuse large B cell lymphoma (DLBCL) spreads quickly and needs immediate attention. The major problem with lymphomas is that they find a ready conduit to spread throughout the body in the lymph system, so surgery is often not an option. r/r NHL means NHL that has relapsed and cannot be surgically treated; ie, most NHL. Millions of people in the world have some form of lymphoma, including NHL.

R-CHOP or Rituximab and a set of four chemotherapy drugs cyclophosphamide, doxorubicin, vincristine, and prednisone are the SoC or standard of care for NHL.

What is a monoclonal antibody?

A monoclonal antibody or mAb is an antibody produced in the laboratory from a single ancestral plasma cell

What Is Non-Hodgkin Lymphoma?

Non-Hodgkin lymphoma (also known as non-Hodgkin’s lymphoma or NHL) is a cancer of the lymphocytes, a type of white blood cells and an important part of the immune system.

What is INI1 and SMARCA4?

INI1 and SMARCA4 are subunits of SWI/SNF, a chromatin modifying protein complex, which opposes the activity of PRC2, the complex within which EZH2 resides.